We are a chemical biology laboratory focused on the development of technologies to map molecules, cells, and functional circuits. We apply the technologies to understand signaling in the mitochondria and mammalian brain.
Our technologies draw from protein engineering, directed evolution, chemical synthesis, high-resolution microscopy, genetics, and computational analysis.
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4/4 Trans-cellular BRET from Luciferase to an optogenetic actuator enables sensitive detection of cell-cell interac… https://t.co/nzZ8mwQgsa
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3/4 Logic AND gates are powerful for increasing specificity in biology. We found that a *nested* AND gate design (F… https://t.co/SpttdeaYt2
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2/4 LOV-based tools/actuators include iLID, Tulips, LOVTRAP, miniSOG, FKF1, Magnets, BLINK, RGS-LOV. Work of… https://t.co/xFLA680rjE
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1/4 Instead of direct stim with blue light, we found that the LOV domain can be opened with Luciferase via proximit… https://t.co/ZWEW90Jr32